My talk will focus on presenting a multimodal spatial-omics atlas of the progression from normal-appearing tissue (NAT) to lung adenocarcinoma (LUAD), revealing critical cellular changes and molecular drivers of early cancer development. By analyzing patient samples and using advanced mouse models, we identified key interactions between progenitor cells, immune cells, and inflammatory signals that promote this transition. Notably, we highlight how specific inflammatory pathways, such as IL-1b signaling, contribute to tumor progression. This atlas offers a comprehensive view of the earliest steps in lung cancer, providing new insights and potential targets for early detection and therapeutic intervention.
